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发布于:2018-2-10 05:47:55  访问:1 次 回复:0 篇
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Here Is How Everolimus Could Impact On Almost All Of Us
There are several potential limitations of this study. First, this analysis was restricted to autosomal SNPs, although we do not expect that many BMD-associated SNPs will be located on the sex chromosomes, as there is not much of Talazoparib X-linked heritability of BMD. Second, areal BMD, despite being a sexually dimorphic phenotype, is not necessarily the most optimal skeletal phenotype because it does not adequately represent bone size. To avoid identifying genes responsible for bone size, we adjusted for height in the model to account for this concern. We also repeated our analysis without height adjustment, and the results were very similar. However, given the limitation of 2D aBMD, volumetric density measures would also be worth assessing in future genetic studies of sex differences in bone. Third, our analyses were corrected for body weight and height, which are important determinants of the skeletal differences observed between men and women. From this perspective, gene-sex Selleck Palbociclib interaction effects influencing BMD variation through weight and height (size) parameters would have been missed. We evaluated here (mostly) direct skeletal effects. Finally, despite our large sample size, we did not identify genome-wide significant SNP-by-sex interactions from using 25,353 individuals for the discovery stage followed by 24,763 individuals for replication. As shown in Fig. 1, with the sample of size 50,000, we would have 80% power to detect gene-by-sex interaction effect of 0.018 or larger in LSBMD (SD?=?0.187) for the SNP (which explains around 0.08% variation of a quantitative trait) with minor allele frequency of 0.25. With 25,353 individuals in Everolimus the discovery stage, we did not have adequate power to identify interaction reaching a genome-wide significant level (p?
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